Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Modeling the segment polarity gene network First: System is biologically defined; known expression patterns
 

Summary: Modeling the segment polarity gene network
First: System is biologically defined; known expression patterns
Input: segment polarity genes
Hypotheses:
continuous model: transcription factors act as enzymes
Boolean model: mRNA and protein activity is switch-like
Validation: reproduces known gene expression patterns.
Explored: changes in kinetic parameters
mutations
changes in initial conditions
Insight: topology is a main source of robustness.
G. von Dassow et al., Nature 406, 188 (2000)
R. Albert, H. G. Othmer, Journ. Theor. Biol. 223, 1 (2003)
M. Chaves, R. Albert, E. Sontag Journ. Theor. Bio. 235, 431 (2005).
M. Chaves, E. Sontag, R. Albert, IEE Proc. Systems Biology 153, 154 (2006).
Segmentation of the fruit fly embryo
ˇ Cell differentiation is based on differential gene expression.
ˇ The segment polarity genes determine and maintain the parasegment
borders.
Syncytial blastoderm, 1h End of gastrulation, 7h

  

Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University

 

Collections: Biology and Medicine