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Current Biology, Vol. 13, 13111316, August 5, 2003, 2003 Elsevier Science Ltd. All rights reserved. DOI 10.1016/S0960-9822(03)00539-6 A Genome-Wide Screen Identifies 27 Genes
 

Summary: Current Biology, Vol. 13, 1311­1316, August 5, 2003, 2003 Elsevier Science Ltd. All rights reserved. DOI 10.1016/S0960-9822(03)00539-6
A Genome-Wide Screen Identifies 27 Genes
Involved in Transposon Silencing in C. elegans
been isolated in which Tc1 transposition is activated in
the germline of the Bristol N2 strain [2, 7]. Interestingly,
half of the mutator mutants are also defective in the
Nadine L. Vastenhouw,1,4
Sylvia E.J. Fischer,1,3,4
Vale´ rie J.P. Robert,1
Karen L. Thijssen,1
Andrew G. Fraser,2
Ravi S. Kamath,2
Julie Ahringer,2
and Ronald H.A. Plasterk1,
* gene-silencing process RNAi [2]. These include alleles
of the four mut genes that have been identified so far:1
Hubrecht Laboratory and Center for
Biomedical Genetics mut-7, a gene with homology to E. coli RNaseD [2],
mut-8 (Tops et al., submitted), mut-14, a DEAD boxUppsalalaan 8
3584 CT Utrecht helicase [8], and mut-15 (Ketting et al., personal commu-

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine