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Carbonic Anhydrase: New Insights for an

Summary: Carbonic Anhydrase:
New Insights for an
Ancient Enzyme*S
Published, JBC Papers in Press, November 5, 2001,
DOI 10.1074/jbc.R100045200
Brian C. Tripp§, Kerry Smith¶,
and James G. Ferry
From the Department of Biochemistry and Molecular
Biology, Eberly College of Science, Pennsylvania State
University, University Park, Pennsylvania 16802-4500
Carbonic anhydrase catalyzes the reversible hydration of CO2
(Equation 1).
CO2 H2O ^ HCO3 H (Eq. 1)
The first carbonic anhydrase was purified from erythrocytes in
1933 (1) followed by the characterization of several mammalian
isozymes that dominated research on carbonic anhydrase until
recently. Although it has been known since the 1940s that carbonic
anhydrase is ubiquitous in plants (2), where it is essential for CO2
fixation, relatively few studies had been reported. Until 1994, only
five carbonic anhydrases had been purified from prokaryotes; how-


Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University
Ferry, James G. - Department of Biochemistry and Molecular Biology, Pennsylvania State University


Collections: Biology and Medicine