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Shape of Phospholipid/Surfactant Mixed Micelles: Cylinders or Disks? Theoretical M. M. Kozlov,*, D. Lichtenberg, and D. Andelman
 

Summary: Shape of Phospholipid/Surfactant Mixed Micelles: Cylinders or Disks? Theoretical
Analysis
M. M. Kozlov,*, D. Lichtenberg, and D. Andelman
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel AViV UniVersity,
Ramat-AViV 69978, Israel, and School of Physics and Astronomy, Raymond and BeVerly Sackler
Faculty of Exact Sciences, Tel AViV UniVersity, Ramat-AViV 69978, Israel
ReceiVed: January 23, 1997; In Final Form: April 14, 1997X
We develop a theoretical model for the solubilization of phospholipid bilayers by micelle-forming surfactants.
Cylindrical micelles, disklike micelles, and spherical micelles are considered as alternative resultant structures.
The main question addressed is, what kind of micelles can be expected under various thermodynamical
conditions? Our analysis is based on a theoretical model that accounts for Helfrich energy of curvature of
amphiphile monolayers and for the entropy of mixing of lipids and surfactants in mixed aggregates. We
conclude that for usual values of the elastic parameters of amphiphile monolayers cylindrical micelles are the
most probable aggregates resulting from micellization of phospholipid by surfactants. This conclusion is
consistent with available experimental data. Conditions of formation of disklike and spherical micelles are
also determined.
Introduction
Amphiphiles tend to self-assemble in aqueous solutions,
mostly due to the hydrophobic effect.1 In the resultant ag-
gregates, the amphiphilic molecules are packed as monolayers,

  

Source: Andelman, David - School of Physics and Astronomy, Tel Aviv University

 

Collections: Materials Science; Physics