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Summary: The Ndc80 Kinetochore Complex Forms
Load-Bearing Attachments to Dynamic
Microtubule Tips via Biased Diffusion
Andrew F. Powers,1,5 Andrew D. Franck,1,5 Daniel R. Gestaut,2,5 Jeremy Cooper,1 Beth Gracyzk,2 Ronnie R. Wei,3,4
Linda Wordeman,1 Trisha N. Davis,2 and Charles L. Asbury1,*
1Department of Physiology and Biophysics
2Department of Biochemistry
University of Washington, Seattle, WA 98195, USA
3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
4Present address: Genzyme Corporation, Framingham, MA 01701, USA
5These authors contributed equally to this work
*Correspondence: casbury@u.washington.edu
DOI 10.1016/j.cell.2008.12.045
SUMMARY
Kinetochores couple chromosomes to the assem-
bling and disassembling tips of microtubules,
a dynamic behavior that is fundamental to mitosis
in all eukaryotes but poorly understood. Genetic,
biochemical, and structural studies implicate the
Ndc80 complex as a direct point of contact between
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