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Annu. Rev. Cell Dev. Biol. 2004. 20:285308 doi: 10.1146/annurev.cellbio.20.011403.154124
 

Summary: Annu. Rev. Cell Dev. Biol. 2004. 20:285308
doi: 10.1146/annurev.cellbio.20.011403.154124
Copyright c 2004 by Annual Reviews. All rights reserved
First published online as a Review in Advance on June 18, 2004
DORSAL-VENTRAL PATTERNING AND NEURAL
INDUCTION IN XENOPUS EMBRYOS
Edward M. De Robertis and Hiroki Kuroda
Howard Hughes Medical Institute, Department of Biological Chemistry, University of
California, Los Angeles, California 90095-1662, email: ederobertis@mednet.ucla.edu,
hkuroda@mednet.ucla.edu
Key Words beta-Catenin, Chordin, Noggin, Xnr3, Cerberus, sFRP, Frzb,
Crescent, Dickkopf, Crossveinless-2, Tsg, Xolloid-related, Bambi, Sizzled, FGF,
IGF, Urbilateria
Abstract We review the current status of research in dorsal-ventral (D-V) pat-
terning in vertebrates. Emphasis is placed on recent work on Xenopus, which provides a
paradigm for vertebrate development based on a rich heritage of experimental embryol-
ogy. D-V patterning starts much earlier than previously thought, under the influence of
a dorsal nuclear -Catenin signal. At mid-blastula two signaling centers are present on
the dorsal side: The prospective neuroectoderm expresses bone morphogenetic protein
(BMP) antagonists, and the future dorsal endoderm secretes Nodal-related mesoderm-

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine