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The Journal of Neuroscience, March 1, 1996, 16(5):1827-1835 Tissue-Specific Expression of a Ca*+-Activated K+ Channel Is
 

Summary: The Journal of Neuroscience, March 1, 1996, 16(5):1827-1835
Tissue-Specific Expression of a Ca*+-Activated K+ Channel Is
Controlled by Multiple Upstream Regulatory Elements
Robert Brenner, Tarita 0. Thomas, Marie N. Becker, and Nigel S. Atkinson
Department of Zoology, The University of Texas at Austin, Austin, Texas 78712- 1064
The electrical properties of a cell are produced by the comple-
ment of ion channels that it expresses. To understand how
ion-channel gene expression is regulated, we are studying the
tissue-specific regulation of the slowpoke (s/o) Ca'+-activated
K' channel gene. This gene is expressed in the central and
peripheral nervous system, in midgut and tracheal cells, and in
the musculature of Drosophila melanogaster. The entire tran-
scriptional control region has been cloned previously and
shown to reproduce the tissue and developmental expression
pattern of the endogenous gene.
Here we demonstrate that s/o has at least four promoters
distributed over -4.5 kb of DNA. Promoter Cl and Cl c display
a TATA box-like sequence at the appropriate distance from the
transcription start site. Promoters Cl b and C2, however, are
TATA-less promoters. Cl, Cl b, and Cl c transcripts differ in

  

Source: Atkinson, Nigel - Section of Neurobiology, Division of Biological Sciences, University of Texas at Austin

 

Collections: Biology and Medicine