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Current Biology, Vol. 13, 14991505, September 2, 2003, 2003 Elsevier Science Ltd. All rights reserved. DOI 10.1016/S0960-9822(03)00577-3 TAC-1, a Regulator of Microtubule Length
 

Summary: Current Biology, Vol. 13, 14991505, September 2, 2003, 2003 Elsevier Science Ltd. All rights reserved. DOI 10.1016/S0960-9822(03)00577-3
TAC-1, a Regulator of Microtubule Length
in the C. elegans Embryo
events, we analyzed 491 (50%) RNAi-induced embry-
onic lethals identified in [6] and [7] by using DIC videomi-
croscopy (see the Experimental Procedures). For this
Nathalie Le Bot, Miao-Chih Tsai,
Robert K. Andrews, and Julie Ahringer*
Wellcome Trust/Cancer Research UK Institute
for Developmental Biology study, we looked for genes whose inactivation by RNAi
led to a specific failure of both pronuclei to migrate,Tennis Court Road
Cambridge CB2 1QR excluding those with additional defects in the pronuclear
envelope or where no spindle was made. The genesUnited Kingdom
identified fall into three different categories linked to
regulation of microtubule-dependent functions.
The first class comprises Prefoldin subunits 2 and 3Summary
(Table 1). The corresponding proteins in Saccharomyces
cerevisiae, Pac10 and Gim4p, are components of theRegulation of microtubule growth is critical for many
Gim protein folding complex, which promotes the forma-cellular processes, including meiosis, mitosis, and nu-
tion of functional - and -tubulin in S. cerevisiae [8].clear migration. We carried out a genome-wide RNAi

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine