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Proc. Natl. Acad. Sci. USA Vol. 92, pp. 4189-4196, May 1995
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 92, pp. 4189-4196, May 1995
Colloquium Paper
This paper was presented at a colloquium entitled "Self-Defense by Plants: Induction and Signalling Pathways,"
organized by Clarence A. Ryan, Christopher J. Lamb, Andre T. Jagendorf, and Pappachan E. Kolattukudy,
held September 15-17, 1994, by the National Academy of Sciences, in Irvine, CA.
Use ofArabidopsis thaliana defense-related mutants to dissect
the plant response to pathogens
FREDERICK M. AUSUBEL*, FUMIAKI KATAGIRI, MICHAEL MINDRINOS, AND JANE GLAZEBROOK
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114
ABSTRACT The plant defense response to microbial
pathogens had been studied primarily by using biochemical
and physiological techniques. Recently, several laboratories
have developed a variety ofpathosystems utilizingArabidopsis
thaliana as a model host so that genetic analysis could also be
used to studyplantdefense responses. Utilizinga pathosystem
that involves the infection of Arabidopsis with pathogenic
pseudomonads, we have cloned the Arabidopsis disease-resis-
tance gene RPS2, which corresponds to the avirulence gene
avrRpt2 in a gene-for-gene relationship. RPS2 encodes a

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine