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Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1348113486, November 1996
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 93, pp. 1348113486, November 1996
Colloquium Paper
This paper was presented at a colloquium entitled ``Memory: Recording Experience in Cells and Circuits,'' organized by
Patricia S. Goldman-Rakic, held February 1720, 1996, at the National Academy of Sciences in Irvine, CA.
Memory from the dynamics of intrinsic membrane currents
(neuronal oscillators plateau neurons neuromodulation dynamic clamp)
EVE MARDER*, L. F. ABBOTT, GINA G. TURRIGIANO, ZHENG LIU, AND JORGE GOLOWASCH
Volen Center and Biology Department, Brandeis University, Waltham, MA 02254
ABSTRACT Almost all theoretical and experimental
studies of the mechanisms underlying learning and memory
focus on synaptic efficacy and make the implicit assumption
that changes in synaptic efficacy are both necessary and
sufficient to account for learning and memory. However,
network dynamics depends on the complex interaction be-
tween intrinsic membrane properties and synaptic strengths
and time courses. Furthermore, neuronal activity itself mod-
ifies not only synaptic efficacy but also the intrinsic membrane
properties of neurons. This paper presents examples demon-
strating that neurons with complex temporal dynamics can

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine