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Dynamics of Dendritic Cell Phenotype and Interactions with CD4 T Cells in Airway Inflammation and Tolerance1
 

Summary: Dynamics of Dendritic Cell Phenotype and Interactions with
CD4 T Cells in Airway Inflammation and Tolerance1
Timothy B. Oriss,* Marina Ostroukhova,* Carole Seguin-Devaux,* Barbara Dixon-McCarthy,*
Donna B. Stolz,
Simon C. Watkins,
Brendan Pillemer,* Prabir Ray,* and Anuradha Ray2
*
An emerging concept is that different types of dendritic cells (DCs) initiate different immune outcomes, such as tolerance vs
inflammation. In this study, we have characterized the DCs from the lung draining lymph nodes of mice immunized for allergic
airway inflammation or tolerance and examined their interactions with CD4 T cells. The DC population derived from tolerized
mice was predominantly CD11c , B220 , Gr-1 , CD11b , and MHC class IIlow
, which resembled plasmacytoid-type DCs whereas
DCs from the inflammatory condition were largely CD11c , B220 , Gr-1 , CD11b , and MHC class IIhigh
resembling myeloid-
type DCs. The DCs from the tolerogenic condition were poor inducers of T cell proliferation. DCs from both conditions induced
T cell IL-4 production but the T cells cultured with tolerogenic DCs were unresponsive to IL-4 as indicated by inhibition of STAT6
activation and expression of growth factor-independent 1, which has been recently shown to be important for STAT6-activated
Th2 cell expansion. Our data suggest that airway tolerance vs inflammation is determined by the DC phenotype in lung draining
lymph nodes. The Journal of Immunology, 2005, 174: 854863.
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Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology