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JOURNALOFNEUROPHYSIOLOGY Vol. 69, No. 3, March 1903. I't-rrltd it1i'.S.. 1.
 

Summary: JOURNALOFNEUROPHYSIOLOGY
Vol. 69, No. 3, March 1903. I't-rrltd it1i'.S.. 1.
RAPID PUBLICATION
Dynamic Clamp: Computer-Generated Conductances in Real Neurons
ANDREW A. SHARP, MICHAEL B. O'NEIL, L. F. ABBOTT, AND EVE MARDER
Departments of Biology and Physics, and Center for. I Complex Systems,v
Brandeis University, Waltham, Massachusetts 02254
SUMMARY AND CONCLUSIONS
I. We describe a new method, the dynamic clamp, that uses a
computer as an interactive tool to introduce simulated voltage and
ligand mediated conductances into real neurons.
2. We simulate a y-aminobutyric acid (GABA) response of a
cultured stomatogastric ganglion neuron to illustrate that the dy-
namic clamp effectively introduces a conductance into the target
neuron.
3. To demonstrate an artificial voltage-dependent conduc-
tance, we simulate the action of a voltage-dependent proctolin
response on a neuron in the intact stomatogastric ganglion. We
show that shifts in the activation curve and the maximal conduc-
tance of the response produce different effects on the target neu-

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine