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DEVELOPMENTS IN FILARIASIS RESEARCH Andrew S. MacDonald P'ng Loke
 

Summary: DEVELOPMENTS IN FILARIASIS RESEARCH
Andrew S. MacDonald P'ng Loke
Robert Martynoga Ian Dransfield Judith E. Allen
Cytokine-dependent inflammatory cell recruitment patterns
in the peritoneal cavity of mice exposed to the parasitic nematode
Brugia malayi
Received: 22 July 2002 / Accepted: 23 August 2002 / Published online: 12 December 2002
Springer-Verlag 2002
Abstract Mice exposed intraperitoneally to either adult
or first larval stage (microfilaria) of the human nema-
tode parasite Brugia malayi display polarized cytokine
responses. We have used this model to investigate the
impact of altered cytokine profiles on inflammatory cell
recruitment patterns in vivo. Here we demonstrate that
Th2-inducing adult parasites drive the recruitment of
eosinophils and macrophages after implant into the
murine peritoneal cavity whereas Th1-inducing micro-
filaria do not. The underlying mechanism of recruitment
was further defined by use of mice deficient in the key
Th2 cytokines IL-4 or IL5 and mice that lack T cells

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh
MacDonald, Andrew - Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh
Maizels, Rick - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine; Environmental Sciences and Ecology