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Failure of Averaging in the Construction of a Conductance-Based Neuron Model
 

Summary: Failure of Averaging in the Construction of a Conductance-Based
Neuron Model
JORGE GOLOWASCH,1
MARK S. GOLDMAN,1,2
L. F. ABBOTT,1
AND EVE MARDER1
1
Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham 02454; and
2
Department of Physics, Harvard University, Cambridge, Massachusetts 02138
Received 18 May 2001; accepted in final form 5 October 2001
Golowasch, Jorge, Mark S. Goldman, L. F. Abbott, and Eve
Marder. Failure of averaging in the construction of a conductance-
based neuron model. J Neurophysiol 87: 11291131, 2002; 10.1152/
jn.00412.2001. Parameters for models of biological systems are often
obtained by averaging over experimental results from a number of
different preparations. To explore the validity of this procedure, we
studied the behavior of a conductance-based model neuron with five
voltage-dependent conductances. We randomly varied the maximal
conductance of each of the active currents in the model and identified

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine