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Summary: The Rockefeller University Press $30.00
J. Exp. Med. Vol. 206 No. 5 1019-1027
www.jem.org/cgi/doi/10.1084/jem.20081621
1019
BRIEF DEFINITIVE REPORT
Activation of a tissue-specific locus involves mul-
tiple epigenetic changes that are brought about
by cis-regulatory sequences. However, the order
or regulation of these changes is poorly under-
stood for any mammalian gene. The -globin
gene cluster is one of the best characterized in
terms of epigenetic regulation. In this locus, a
region encompassing the four -like genes is in
a DNase Isensitive configuration and associ-
ated with acetylated histones H3 and H4 in the
erythroid lineage (1, 2). A cluster of DNase I
hypersensitive sites (HS) comprise a locus con-
trol region that is essential for high-level tran-
scription but not for erythroid-specific histone
hyperacetylation or DNase I sensitivity (35).
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