Summary: Long-Lived C. elegans daf-2
Mutants Are Resistant to
Bacterial Pathogens
Danielle A. Garsin,1,3
Jacinto M. Villanueva,1,3
Jakob Begun,1,3
Dennis H. Kim,1,3
Costi D. Sifri,2,4
Stephen B. Calderwood,2,4
Gary Ruvkun,1,3
Frederick M. Ausubel1,3
*
Our laboratories have studied the mecha-
nisms of aging (1, 2) and immune function
(3) in Caenorhabditis elegans. Herein we
show that the mechanisms that govern these
two processes may be interrelated.
The human Gram-negative bacterial patho-
gens Pseudomonas aeruginosa and Salmonella
enterica and the Gram-positive pathogens En-

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

Collections: Biology and Medicine