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Long-Lived C. elegans daf-2 Mutants Are Resistant to

Summary: Long-Lived C. elegans daf-2
Mutants Are Resistant to
Bacterial Pathogens
Danielle A. Garsin,1,3
Jacinto M. Villanueva,1,3
Jakob Begun,1,3
Dennis H. Kim,1,3
Costi D. Sifri,2,4
Stephen B. Calderwood,2,4
Gary Ruvkun,1,3
Frederick M. Ausubel1,3
Our laboratories have studied the mecha-
nisms of aging (1, 2) and immune function
(3) in Caenorhabditis elegans. Herein we
show that the mechanisms that govern these
two processes may be interrelated.
The human Gram-negative bacterial patho-
gens Pseudomonas aeruginosa and Salmonella
enterica and the Gram-positive pathogens En-


Source: Ausubel, Frederick M. - Department of Genetics, Harvard University


Collections: Biology and Medicine