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Research Focus The dynamic personality of TATA-binding protein
 

Summary: Research Focus
The dynamic personality of TATA-binding protein
David T. Auble
Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
TATA-binding protein (TBP) is a central component of
the transcription apparatus and its association with
promoters is dynamically regulated genome-wide.
Recent work has shed new light on the functional speci-
ficity of Mot1 and NC2, two factors that control TBP
distribution and activity. These studies underscore how
regulation of TBP globally influences fundamental
aspects of gene expression, including the balance of
transcriptional output from different types of promoters,
and the amplitude and timing of gene activation.
TATA-binding protein: linchpin of the RNA polymerase
II preinitiation complex
Transcription is regulated by myriad mechanisms, many of
which affect RNA polymerase II (Pol II) preinitiation com-
plex (PIC) assembly. Although there is an increasing
appreciation of the diversity and specialization in PIC

  

Source: Auble, David - Department of Biochemistry and Molecular Genetics, University of Virginia

 

Collections: Biology and Medicine