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Increases in estrogen receptor-concentration in breast cancer cells promote serine 118/104/106-
 

Summary: Increases in estrogen receptor- concentration in
breast cancer cells promote serine 118/104/106-
independent AF-1 transactivation and growth in the
absence of estrogen
AMY M. FOWLER, NATALIA SOLODIN, MARA T. PREISLER-MASHEK, PING ZHANG,*
ADRIAN V. LEE,* AND ELAINE T. ALARID1
Department of Physiology, University of Wisconsin-Madison, Madison, Wisconsin, USA; and
*The Breast Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
ABSTRACT A common phenotype in breast cancer is
the expansion of the estrogen receptor- (ER ) cell
population and an inappropriate elevation of ER
protein, the latter predisposing patients for a poorer
prognosis than those with lower levels of the receptor.
A tetracycline-inducible ER overexpression model was
developed in the MCF-7 cell line to assess induction of
endogenous gene activation and growth in response to
elevations in ER protein. Heightened levels of ER
resulted in aberrant promoter occupancy and gene
activation in the absence of hormone, which was inde-
pendent of ligand and AF-2 function. This increased

  

Source: Alarid, Elaine T. - Molecular and Cellular Pharmacology Training Program & Department of Oncology,University of Wisconsin at Madison

 

Collections: Biology and Medicine