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Biophysical Journal Volume 72 April 1997 1582-1594 Collective Binding Properties of Receptor Arrays

Summary: Biophysical Journal Volume 72 April 1997 1582-1594
Collective Binding Properties of Receptor Arrays
Noam Agmon and Arieh L. Edelstein
Department of Physical Chemistry and the Fritz Haber Research Center, The Hebrew University, Jerusalem 91904, Israel
ABSTRACT Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate
synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise
and decay ofthe activation probability as a function of the number of transmitter molecules released. Using a realistic receptor
array geometry, the simulation reproduces the time course of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid re-
ceptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents
in terms of rebinding and spatial correlations is discussed.
The reversible binding of ligands (hormones, neurotrans-
mitters) to an array of membrane-bound receptors is an
important mechanism of intercellular communication. In
particular, the mechanism of synaptic transmission has been
extensively studied. Examples of important chemical syn-
apses involve the nicotinic acetylcholine (ACh) receptor
(Magleby and Stevens, 1972; Katz and Miledi, 1973) at the
vertebrate neuromuscular junction (NMJ) and glutamate
receptors (Eccles and Jaeger, 1958; Kom and Faber, 1991;


Source: Agmon, Noam - Institute of Chemistry, Hebrew University of Jerusalem


Collections: Chemistry