Summary: Inference methods
· Probabilistic methods
­ Clustering analysis
­ Data mining
­ Bayesian networks
· Deterministic methods
­ Continuous ­ Differential equations
­ Discrete - Boolean
Four steps in clustering analysis
· Pair-wise correlation analysis
­ Time-series data
­ spatial data
· Gene co-expression network
· Clustering of genes
· Predicting protein-protein interaction
Drawback: No insight into the causal relationship
Pair-wise similarities between expression profiles:
· Pearson correlation
· Squared Pearson correlation coefficient
· Spearman rank correlation

Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University

Collections: Biology and Medicine