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The transthyretin-related protein family Therese Eneqvist1,2

Summary: The transthyretin-related protein family
Therese Eneqvist1,2
, Erik Lundberg1
, Lars Nilsson1
, Ruben Abagyan2
and A. Elisabeth Sauer-Eriksson1
Umea° Centre for Molecular Pathogenesis, Umea° University, Sweden; 2
Department of Molecular Biology, The Scripps Research
Institute, La Jolla, California, USA
A number of proteins related to the homotetrameric trans-
port protein transthyretin (TTR) forms a highly conserved
protein family, which we present in an integrated analysis of
data from different sources combined with an initial bio-
chemical characterization. Homologues of the transthyretin-
related protein (TRP) can be found in a wide range of species
including bacteria, plants and animals, whereas transthyre-
tinshavesofar onlybeenidentifiedinvertebrates. Amultiple
sequence alignment of 49 TRP sequences from 47 species to
TTR suggests that the tertiary and quaternary features of the


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine