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Gene Duplication and the Evolution of Group II Chaperonins: Implications for Structure and Function
 

Summary: Gene Duplication and the Evolution of Group II Chaperonins:
Implications for Structure and Function
John M. Archibald, Christian Blouin, and W. Ford Doolittle
Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology,
Dalhousie University, Halifax, Nova Scotia, Canada
Received January 31, 2001, and in revised form March 27, 2001; published online July 23, 2001
Chaperonins are multisubunit protein-folding
assemblies. They are composed of two distinct
structural classes, which also have a characteris-
tic phylogenetic distribution. Group I chaper-
onins (called GroEL/cpn60/hsp60) are present in
Bacteria and eukaryotic organelles while group II
chaperonins are found in Archaea (called the
thermosome or TF55) and the cytoplasm of eu-
karyotes (called CCT or TriC). Gene duplication
has been an important force in the evolution of
group II chaperonins: Archaea possess one, two,
or three homologous chaperonin subunit-encod-
ing genes, and eight distinct CCT gene families
(paralogs) have been described in eukaryotes.

  

Source: Archibald, John - Department of Biochemistry and Molecular Biology, Dalhousie University

 

Collections: Biology and Medicine