Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Brief Genetics Report Identification of Major Quantitative Trait Loci
 

Summary: Brief Genetics Report
Identification of Major Quantitative Trait Loci
Controlling Body Weight Variation in ob/ob Mice
Jonathan P. Stoehr,1
Jessica E. Byers,2
Susanne M. Clee,1
Hong Lan,1
Igor V. Boronenkov,1
Kathryn L. Schueler,1
Brian S. Yandell,3
and Alan D. Attie1
The adipocyte hormone leptin constitutes an important
component of the regulation of energy homeostasis;
leptin-deficient animals, such as obese mice, are strik-
ingly overweight. The seemingly uninhibited weight gain
in obese mice belies the fact that control of energy
homeostasis remains under precise, heritably modifi-
able control. Herein, we report large, heritable differ-
ences in body weight and food intake between BTBR-
ob/ob and B6-ob/ob mice. We have identified two loci,

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison
Yandell, Brian S. - Departments of Statistics & Horticulture, University of Wisconsin at Madison

 

Collections: Biology and Medicine; Mathematics