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Summary: Brief Genetics Report
Identification of Major Quantitative Trait Loci
Controlling Body Weight Variation in ob/ob Mice
Jonathan P. Stoehr,1
Jessica E. Byers,2
Susanne M. Clee,1
Hong Lan,1
Igor V. Boronenkov,1
Kathryn L. Schueler,1
Brian S. Yandell,3
and Alan D. Attie1
The adipocyte hormone leptin constitutes an important
component of the regulation of energy homeostasis;
leptin-deficient animals, such as obese mice, are strik-
ingly overweight. The seemingly uninhibited weight gain
in obese mice belies the fact that control of energy
homeostasis remains under precise, heritably modifi-
able control. Herein, we report large, heritable differ-
ences in body weight and food intake between BTBR-
ob/ob and B6-ob/ob mice. We have identified two loci,
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