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Summary: Neuron
Clinical Study
The Brain in Chronic CRPS Pain:
Abnormal Gray-White Matter Interactions
in Emotional and Autonomic Regions
Paul Y. Geha,1 Marwan N. Baliki,1 R. Norman Harden,2 William R. Bauer,6 Todd B. Parrish,3 and A. Vania Apkarian1,4,5,*
1Department of Physiology
2Rehabilitation Institute
3Department of Radiology
4Department of Anesthesia
5Department of Surgery
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
6Department of Neuroscience, University of Toledo, 3000 Arlington Avenue, Toledo OH 43614-2598, USA
*Correspondence: a-apkarian@northwestern.edu
DOI 10.1016/j.neuron.2008.08.022
SUMMARY
Chronic complex regional pain syndrome (CRPS) is
a debilitating pain condition accompanied by auto-
nomic abnormalities. We investigated gray matter
morphometry and white matter anisotropy in CRPS
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