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Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.105.052050

Summary: Copyright Ó 2007 by the Genetics Society of America
DOI: 10.1534/genetics.105.052050
Intergenomic Epistasis for Fitness: Within-Population Interactions Between
Cytoplasmic and Nuclear Genes in Drosophila melanogaster
Damian K. Dowling,*,1
Urban Friberg,*,
Frank Hailer* and Go¨ran Arnqvist*
*Animal Ecology/Department of Ecology and Evolution, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala,
Sweden and
Department of Ecology and Environmental Science, Umea° University, SE-901 87 Umea°, Sweden
Manuscript received October 6, 2005
Accepted for publication October 19, 2006
The symbiotic relationship between the mitochondrial and nuclear genomes coordinates metabolic
energy production and is fundamental to life among eukaryotes. Consequently, there is potential for strong
selection to shape interactions between these two genomes. Substantial research attention has focused on
the possibility that within-population sequence polymorphism in mitochondrial DNA (mtDNA) is
maintained by mitonuclear fitness interactions. Early theory predicted that selection will often eliminate
mitochondrial polymorphisms. However, recent models demonstrate that intergenomic interactions can
promote the maintenance of polymorphism, especially if the nuclear genes involved are linked to the X


Source: Arnqvist, Göran - Department of Animal Ecology, Uppsala Universitet
Dowling, Damian - School of Biological Sciences, Monash University


Collections: Biology and Medicine; Environmental Sciences and Ecology