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Molecular basis of a progressive juvenile-onset hereditary cataract

Summary: Molecular basis of a progressive juvenile-onset
hereditary cataract
Ajay Pande*, Jayanti Pande
, Neer Asherie
, Aleksey Lomakin
, Olutayo Ogun
, Jonathan A. King*, Nicolette H. Lubsen
David Walton§
, and George B. Benedek¶
Departments of *Biology, and Physics, Center for Materials Science and Engineering, and Materials Processing Center, Massachusetts Institute of
Technology, Cambridge, MA 02139-4307; Department of Biochemistry, University of Nijmegen, 6500 HB Nijmegen, The Netherlands; and §Department of
Pediatric Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114-3130
Contributed by George B. Benedek, December 17, 1999
In a recent paper, patients with a progressive juvenile-onset
hereditary cataract have been reported to have a point mutation
in the human D crystallin gene (Stephan, D. A., Gillanders, E.,
Vanderveen, D., Freas-Lutz, D., Wistow, G., Baxevanis, A. D.,
Robbins, C. M., VanAuken, A., Quesenberry, M. I., Bailey-Wilson, J.,
et al. (1999) Proc. Natl. Acad. Sci. USA 96, 1008­1012). This mutation


Source: Asherie, Neer - Departments of Physics & Biology, Yeshiva University
Benedek, George B. - Department of Physics, Massachusetts Institute of Technology (MIT)


Collections: Biology and Medicine; Physics