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Pore-forming toxins and cellular non-immune defenses (CNIDs) Raffi Aroian1

Summary: Pore-forming toxins and cellular non-immune defenses (CNIDs)
Raffi Aroian1
and F G van der Goot2
Pore-forming toxins (PFTs) are the most common class of
bacterial protein toxin and are important for bacterial
pathogenesis. Recent studies have shown that the previous
model stating that epithelial cells lyse in response to these
toxins and have no defenses against these pores is
oversimplified. Rather, it appears that cells have sophisticated
mechanisms and signal-transduction pathways with which to
respond to such an attack. There is a growing body of
knowledge about how cells respond to and protect themselves
against PFTs; this protection against PFTs is likely to be
important in host survival to attack by bacterial pathogens, but
does not neatly fit into current concepts of adaptive or innate
immunity. Therefore, it is proposed that the terminology cellular
non-immune defenses (CNIDs) be used to describe defenses
that are employed by non-immune cells to protect against
bacterial attack.


Source: Aroian, Raffi V. - Division of Biological Sciences, University of California at San Diego


Collections: Biology and Medicine