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Developmental Cell A Casein Kinase 1 and PAR Proteins

Summary: Developmental Cell
A Casein Kinase 1 and PAR Proteins
Regulate Asymmetry of a PIP2 Synthesis Enzyme
for Asymmetric Spindle Positioning
Costanza Panbianco,1 David Weinkove,2,5 Esther Zanin,4 David Jones,3 Nullin Divecha,2,3 Monica Gotta,4,6
and Julie Ahringer1,*
1The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
2Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
3The Inositide Laboratory, The Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
4Institute of Biochemistry, Building HPM, Room G16.2, ETH Hoenggerberg, 8093-Zuerich, Switzerland
5Present address: Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
6Present address: Department of Genetic Medecine and Development, University of Geneva, Rue Michel Servet 1, 1211 Geneva, Swizerland
*Correspondence: jaa@mole.bio.cam.ac.uk
DOI 10.1016/j.devcel.2008.06.002
Spindle positioning is an essential feature of asym-
metric cell division. The conserved PAR proteins to-
gether with heterotrimeric G proteins control spindle
positioning in animal cells, but how these are linked is


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine