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Arousal and reward: a dichotomy in orexin function
 

Summary: Arousal and reward: a dichotomy in
orexin function
Glenda C. Harris1
and Gary Aston-Jones2
1
Department of Psychiatry, University of Pennsylvania, Translational Research Labs/3403, 125 South 31st Street, Philadelphia,
PA 19104, USA
2
Department of Neurosciences, Medical University of South Carolina, 401 BSB, 173 Ashley Avenue, Charleston, SC 29425, USA
The orexins (or hypocretins) are neuropeptide
transmitters made exclusively in hypothalamic neurons
that have extensive CNS projections. Previous studies
reported that this system is most strongly associated
with feeding, arousal and the maintenance of waking.
We review here recent studies that reveal a novel and
important role for the orexin/hypocretin neuronal sys-
tem in reward processing and addiction. We propose
that the current evidence indicates a dichotomy in orexin
function, such that orexin neurons in the lateral hypotha-
lamus regulate reward processing for both food and

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine