Summary: Immunity, Vol. 9, 267­276, August, 1998, Copyright ©1998 by Cell Press
Targeted Disruption of the Mouse Caspase 8 Gene
Ablates Cell Death Induction by the TNF Receptors,
Fas/Apo1, and DR3 and Is Lethal Prenatally
family that are expressed in the living cell as inactive
precursors and become activated upon death induction.
Once activated, these proteases cleave a specific set of
substrate proteins that act as regulators of the apopto-
tic mechanisms and thus set the apoptotic program in
Eugene E. Varfolomeev,1
Marcus Schuchmann,1
Victor Luria,2
Nuchanard Chiannilkulchai,4,9
Jacques S. Beckmann,4
Igor L. Mett,1
Denis Rebrikov,1
Vadim M. Brodianski,1
Oliver C. Kemper,1
Orit Kollet,3
Tsvee Lapidot,3

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

Collections: Biology and Medicine