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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination
 

Summary: Integrity of the AID serine-38 phosphorylation
site is critical for class switch recombination
and somatic hypermutation in mice
Hwei-Ling Chenga,1
, Bao Q. Vuongb,1
, Uttiya Basua,1
, Andrew Franklina
, Bjoern Schwera
, Jillian Astaritab
, Ryan T. Phana
,
Abhishek Dattaa
, John Manisa
, Frederick W. Alta,2
, and Jayanta Chaudhurib,2
aHoward Hughes Medical Institute, The Children's Hospital; Department of Genetics, Harvard Medical School, and The Immune Disease Institute,
Boston, MA 02115; and bImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
Contributed by Frederick W. Alt, December 10, 2008 (sent for review November 19, 2008)
Activation-induced cytidine deaminase (AID) is a single-stranded
(ss) DNA-specific cytidine deaminase that initiates Ig heavy chain

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine