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J MolEvol(1983) 19:397-410 Journal of MolecularEvolution

Summary: J MolEvol(1983) 19:397-410 Journal of
9 Springer-Verlag 1983
Evolution of aq- and 3-Tubulin Genes as Inferred by the
Nucleotide Sequences of Sea Urchin cDNA Clones
bespina Alexandraki and Joan V. Ruderman
Department of Anatomy, Harvard MedicalSchool, 25 Shattuek Street, Boston, MA02115, USA
Summary.Evolutionary studies on the tubulin multigene
families were initiated by nucleotide sequence analysis
of cDNA clones complementary to sea urchin (Lyte-
chinus pictus) testis a- and 3-tubulin mRNAS. Sequence
COmparisons of three partial 3-tubulin cDNA clones
(P31, pff2, p33) demonstrated the existence of tubulin
rnRNA heterogeneity, p32 and p33 contain identical
tubulin-coding regions and extremely similar 3' untrans-
lated sequences, including a polyadenylation signal
(AAUAAA). However, p132contains an additional region
of 3' untranslated sequence which includes a second
Polyadenylation signal. These two sequences may be
allelic, representing products of alternative transcription


Source: Alexandraki, Despina - Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Hellas


Collections: Biology and Medicine; Biotechnology