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TheJournalofExperimentalMedicine JEM The Rockefeller University Press $8.00

Summary: TheJournalofExperimentalMedicine
JEM The Rockefeller University Press $8.00
Vol. 203, No. 11, October 30, 2006 25192527 www.jem.org/cgi/doi/10.1084/jem.20061692
Specialized cell types in multicellular organisms
are defined by specific patterns of gene expres-
sion (1). In addition to the transcriptional regula-
tion of protein-coding genes, posttranscriptional
regulation is emerging as an important mech-
anism for the control of gene expression. In
particular, the noncoding transcripts of several
hundred micro RNA (miRNA) genes affect
the translation and/or the stability of protein-
coding transcripts (2). Long primary miRNAs
are processed into hairpins of 6070 nucleotides
in length by a complex containing the nuclear
RNase III enzyme Drosha and DGCR8 (Di-
George syndrome critical region 8 homologue;
references 3 and 4). These pre-miRNAs are ex-


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology