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Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1
 

Summary: Simvastatin promotes Th2-type responses through
the induction of the chitinase family member Ym1
in dendritic cells
Meenakshi Arora*, Li Chen*, Melissa Paglia*, Iain Gallagher
, Judith E. Allen
, Yatin M. Vyas§
, Anuradha Ray*§
,
and Prabir Ray*§¶
Departments of *Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine and §Immunology, University of Pittsburgh School
of Medicine, Pittsburgh, PA 15213; Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom;
and Department of Pediatrics, Division of Hematology and Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213
Edited by William E. Paul, National Institutes of Health, Bethesda, MD, and approved March 31, 2006 (received for review September 28, 2005)
Statins, best known for their lipid-lowering actions, also possess
immunomodulatory properties. Recent studies have shown a Th2-
biasing effect of statins, although the underlying mechanism has
not been identified. In this study, we investigated whether sim-
vastatin can exercise a Th2-promoting effect through modulation
of function of dendritic cells (DCs) without direct interaction with
CD4 T cells. Exposure of DCs to simvastatin induced the differ-

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine