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Journal of Theoretical Biology 245 (2007) 433448 Robustness and evolvability in genetic regulatory networks

Summary: Journal of Theoretical Biology 245 (2007) 433­448
Robustness and evolvability in genetic regulatory networks
Maximino Aldanaa,d,Ã, Enrique Ballezaa,d
, Stuart Kauffmanb
, Osbaldo Resendizc,d
Centro de Ciencias Fi´sicas, Universidad Nacional Auto´noma de Me´xico, C.P. 62251, Apartado Postal 48-3, Cuernavaca, Morelos, Mexico
Institute of Biocomplexity and Informatics, University of Calgary, Calgary, Alta., Canada
Centro de Ciencias Geno´micas, UNAM, Cuernavaca, Morelos, Mexico
Consortium for the Americas for Interdisciplinary Science, UNM, Albuquerque, NM, USA
Received 29 March 2006; received in revised form 17 October 2006; accepted 25 October 2006
Available online 1 November 2006
Living organisms are robust to a great variety of genetic changes. Gene regulation networks and metabolic pathways self-organize and
reaccommodate to make the organism perform with stability and reliability under many point mutations, gene duplications and gene
deletions. At the same time, living organisms are evolvable, which means that these kind of genetic perturbations can eventually make the
organism acquire new functions and adapt to new environments. It is still an open problem to determine how robustness and evolvability


Source: Aldana, Maximino - Centro de Ciencias Físicas, Universidad Nacional Autónoma de México


Collections: Physics