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Behavioral/Systems/Cognitive Numerous GABAergic Afferents to Locus Ceruleus in the

Summary: Behavioral/Systems/Cognitive
Numerous GABAergic Afferents to Locus Ceruleus in the
Pericerulear Dendritic Zone: Possible Interneuronal Pool
Gary Aston-Jones,1 Yan Zhu,1 and J. Patrick Card2
1Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and 2Department of Neuroscience, University of Pittsburgh,
Pittsburgh, Pennsylvania 15260
is composed almost entirely of noradrenergic principal neurons. Here, we report that numerous small neurons in the peri-LC region
become retrogradely labeled after focal injections of wheat germ agglutinin­apo (inactivated) horseradish peroxidase conjugated to
colloidal gold, or pseudorabies virus (PRV), into the nuclear core of the rat LC. A substantial number of these neurons were routinely
revealed that a large percentage of these cells stained for GABA. Ultrastructural analyses revealed axodendritic and axosomatic contacts
between PRV-labeled afferents and LC neurons labeled with tyrosine hydroxylase immunohistochemistry. In addition, PRV-labeled
demonstrated that these LC afferents in the peri-LC region receive several non-LC synaptic inputs. These results indicate that a popula-
tion of small GABAergic neurons in the peri-LC dendritic zone may provide interneuronal integration for LC noradrenergic neurons.
Key words: norepinephrine; locus ceruleus; GABA; ultrastructure; interneurons; pseudorabies virus
The brain nucleus locus ceruleus (LC) is the largest source of


Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina


Collections: Biology and Medicine