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Molecular Cell Cost of Unneeded Proteins in E. coli Is Reduced

Summary: Molecular Cell
Cost of Unneeded Proteins in E. coli Is Reduced
after Several Generations in Exponential Growth
Irit Shachrai,1 Alon Zaslaver,3 Uri Alon,1,2,* and Erez Dekel1,2,*
1Department of Molecular Cell Biology
2Department of Physics of Complex Systems
The Weizmann Institute of Science, Rehovot 76100, Israel
3Howard Hughes Medical Institute and California Institute of Technology, Division of Biology, 1200 East California Boulevard, Pasadena,
CA 91125, USA
*Correspondence: urialon@weizmann.ac.il (U.A.), erez.dekel@weizmann.ac.il (E.D.)
DOI 10.1016/j.molcel.2010.04.015
When E. coli cells express unneeded protein, they
grow more slowly. Such penalty to fitness associated
with making proteins is called protein cost. Protein
cost is an important component in the cost-benefit
tradeoffs that underlie the evolution of protein cir-
cuits, but its origins are still poorly understood.
Here, we ask how the protein cost varies during the


Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science


Collections: Biology and Medicine