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Monitoring gastric lymphoma in peripheral blood by quantitative IgH allele-specific oligonucleotide real-time PCR
 

Summary: Monitoring gastric lymphoma in peripheral blood by
quantitative IgH allele-specific oligonucleotide real-time PCR
and API2-MALT1 PCR
Although gastric extranodal marginal zone lymphoma (gastric
EMZL) often shows an indolent clinical behaviour, involve-
ment of bone marrow (1520%), other mucosa-associated
lymphoid tissue (MALT) sites (3050%) (van Krieken et al,
1989; Thieblemont et al, 2000) and peripheral blood (PB)
(Bertoni et al, 2000) of patients with stage I tumours has been
reported. Helicobacter pylori eradication results in lymphoma
regression in 7080% of the low-grade cases, but remission may
occur after several months, necessitating prolonged follow-up.
The translocation t(11;18)(q21;q21), which results in the API2-
MALT1 fusion (Dierlamm et al, 1999), is found in 2030% of
gastric EMZL (Schreuder et al, 2003) and has shown to be
predictive for unresponsiveness to H. pylori eradication treat-
ment for all stages of gastric EMZL (Liu et al, 2002).
Prospective quantitative monitoring of minimal residual
disease in PB has been described for other non-Hodgkin
lymphomas (Mandigers et al, 2001), but the clinical relevance

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine