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Brain Research, 239 (1982) 589-594 589 Elsevier Biomedical Press
 

Summary: Brain Research, 239 (1982) 589-594 589
Elsevier Biomedical Press
KSIliker-Fuse nucleus: the principal source of pontine catecholaminergic
cells projecting to the lumbar spinal cord of cat
RICHARD T. STEVENS, CHARLES J. HODGE, Jr.* and APKAR V. APKARIAN
Department of Nem'osurgery, Upstate Medical Center, 750 East Adams Street, Syracuse, N Y 13210
(U.S.A.)
(Accepted January 28th, 1982)
Key words: K611iker-Fuse nucleus -- ponto-spina[ projections -- catecholamines locus coeruleus
Using retrograde transport of the fluorescent dye Evans Blue (EB), in combination with
glyoxylic acid histofluorescence, the ponto-spinal catecholaminergic pathways were investigated. The
cells which contain catecholamine and project to the lumbar spinal cord of the cat are most densely
concentrated in the Kblliker-Fuse nucleus. Locus coeruleus, the subcoeruleus area, and the
parabrachial nuclei were found to have relatively few cells that both contain catecholamine and
project to the lumbar spinal cord.
Noradrenergic bulbospinal systems have been implicated in a wide variety of
spinal segmental functions, including motor reflex control1,%, modulation of sensory
processing6,12, and vegetative nervous system controlxs. In addition, spinal noradre-
naline (NA) has been thought to play a role in opiate and other segmental analgesic
mechanismslO,~l,z2, 27. Since retrograde and antegrade transport studies have demon-

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine