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Summary: Directed Evolution Study of Temperature Adaptation
in a Psychrophilic Enzyme
Kentaro Miyazaki1
, Patrick L. Wintrode1
, Rowan A. Grayling2
Donn N. Rubingh2
and Frances H. Arnold1
*
1
Division of Chemistry and
Chemical Engineering 210-41
California Institute of
Technology, Pasadena, CA
91125, USA
2
Miami Valley Laboratories
The Procter & Gamble
Company, PO Box 538707
Cincinnati, OH 45253, USA
We have used laboratory evolution methods to enhance the thermostabil-
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