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Current Biology 20, 12441253, July 27, 2010 2010 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2010.06.034 Intercellular Coupling Regulates

Summary: Current Biology 20, 1244­1253, July 27, 2010 ª2010 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2010.06.034
Intercellular Coupling Regulates
the Period of the Segmentation Clock
Leah Herrgen,1 Sau´l Ares,2 Luis G. Morelli,1,2,3
Christian Schro¨ter,1 Frank Ju¨licher,2 and Andrew C. Oates1,*
1Max Planck Institute for Molecular Cell Biology and Genetics,
Pfotenhauerstraße 108, 01307 Dresden, Germany
2Max Planck Institute for the Physics of Complex Systems,
No¨ thnitzer Straße 38, 01187 Dresden, Germany
3Departamento de Fisica, FCEyN, UBA, Pabello´ n I, Ciudad
Universitaria, 1428 Buenos Aires, Argentina
Background: Coupled biological oscillators can tick with the
same period. How this collective period is established is
a key question in understanding biological clocks. We explore
this question in the segmentation clock, a population of
coupled cellular oscillators in the vertebrate embryo that
sets the rhythm of somitogenesis, the morphological segmen-
tation of the body axis. The oscillating cells of the zebrafish


Source: Ares, Saúl - Max-Planck-Institut für Physik komplexer Systeme
Juelicher, Frank - Max-Planck-Institut für Physik komplexer Systeme


Collections: Biology and Medicine; Physics