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BioMed Central Page 1 of 10

Summary: BioMed Central
Page 1 of 10
(page number not for citation purposes)
BMC Cell Biology
Open AccessResearch
Identifying directed links in large scale functional networks:
application to brain fMRI
Guillermo A Cecchi*1, A Ravishankar Rao1, Maria V Centeno2,
Marwan Baliki2, A Vania Apkarian2 and Dante R Chialvo2
Address: 1Computational Biology Center, T.J. Watson IBM Research Center, Yorktwon Heights, New York, USA and 2Dept. of Physiology, Feinberg
School of Medicine, Northwestern University, Chicago, Illinois, USA
Email: Guillermo A Cecchi* - gcecchi@us.ibm.com; A Ravishankar Rao - ravirao@us.ibm.com; Maria V Centeno - m-
centeno@northwestern.edu; Marwan Baliki - m-baliki@northwestern.edu; A Vania Apkarian - a-apkarian@northwestern.edu;
Dante R Chialvo - d-chialvo@northwestern.edu
* Corresponding author
Background: Biological experiments increasingly yield data representing large ensembles of
interacting variables, making the application of advanced analytical tools a forbidding task. We
present a method to extract networks of correlated activity, specifically from functional MRI data,
such that: (a) network nodes represent voxels, and (b) the network links can be directed or


Source: Apkarian, A. Vania - Department of Physiology, Northwestern University


Collections: Biology and Medicine