Summary: Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable
anaerobic 2-methylpropan-1-ol production at theoretical yield in
Escherichia coli
Sabine Bastian a
, Xiang Liu a,1
, Joseph T. Meyerowitz a
, Christopher D. Snow a
, Mike M.Y. Chen a
,
Frances H. Arnold a,n
a
Division of Chemistry and Chemical Engineering, California Institute of Technology, Mail code 210-41, Pasadena, CA 91125, USA
a r t i c l e i n f o
Keywords:
Metabolic engineering
Cofactor imbalance
Isobutanol
Ketol-acid reductoisomerase
Biofuels
a b s t r a c t

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

Collections: Chemistry; Biology and Medicine