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Loss of stearoylCoA desaturase-1 function protects mice against adiposity

Summary: Loss of stearoyl­CoA desaturase-1 function protects
mice against adiposity
James M. Ntambi*
, Makoto Miyazaki*, Jonathan P. Stoehr*, Hong Lan*, Christina M. Kendziorski§
, Brian S. Yandell¶
Yang Song
, Paul Cohen , Jeffrey M. Friedman¶
, and Alan D. Attie*
Departments of *Biochemistry, Nutritional Sciences, §Biostatistics and Medical Informatics, and ¶Statistics and Horticulture, University of Wisconsin,
Madison, WI 53706; and Laboratory of Molecular Genetics and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021
Contributed by Jeffrey M. Friedman, June 28, 2002
Stearoyl­CoA desaturase (SCD) is a central lipogenic enzyme cat-
alyzing the synthesis of monounsaturated fatty acids, mainly
oleate (C18:1) and palmitoleate (C16:1), which are components of
membrane phospholipids, triglycerides, wax esters, and choles-
terol esters. Several SCD isoforms (SCD1-3) exist in the mouse. Here
we show that mice with a targeted disruption of the SCD1 isoform
have reduced body adiposity, increased insulin sensitivity, and are
resistant to diet-induced weight gain. The protection from obesity


Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison
Yandell, Brian S. - Departments of Statistics & Horticulture, University of Wisconsin at Madison


Collections: Biology and Medicine; Mathematics