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Copyright 0 1986 by the Genetics Society of America SELECTION FOR INCREASED MUTATION RATES WITH
 

Summary: Copyright 0 1986 by the Genetics Society of America
SELECTION FOR INCREASED MUTATION RATES WITH
FERTILITY DIFFERENCES BETWEEN MATINGS
K. E. HOLSINGER, M. W. FELDMAN AND L. ALTENBERG
Department of Biological Sciences, Stanford University, Stanford, Calqornia 94305-2493
Manuscript received June 14, 1985
Revised copy accepted November 21, 1985
ABSTRACT
Previous studies of mutation modification have considered models in which
selection is a result of viability differences that are sex symmetric. The results
of a numerical study of a model in which selection is a result of fertility differ-
ences between mated pairs demonstrate that the type of selection to which a
population is subject can have a significant impact on the evolution of various
parameters of the genetic system. When the fertility of matings between individ-
uals with different genotypes exceeds the fertility of at least some of the matings
between individuals with the same genotype, selection may favor increased rates
of mutation, in contrast to the results from all exisitng constant viability models
with random mating and infinite population size. Increased mutation rates are
most frequently favored when forward and back mutation occur at approxi-
mately equal rates and when the modifying locus is loosely linked to the selected

  

Source: Altenberg, Lee - Department of Information and Computer Science, University of Hawai'i at Manoa

 

Collections: Computer Technologies and Information Sciences