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Critical Review Recent Advances in Understanding the Structure of Nicotinic
 

Summary: Critical Review
Recent Advances in Understanding the Structure of Nicotinic
Acetylcholine Receptors
Marios Zouridakis1,2
, Paraskevi Zisimopoulou1
, Konstantinos Poulas2
and Socrates J. Tzartos1,2
1
Department of Biochemistry, Hellenic Pasteur Institute, Athens, Greece
2
Department of Pharmacy, University of Patras, Patras, Greece
Summary
Nicotinic acetylcholine receptors (nAChRs), members of the
Cys-loop ligand-gated ion channels (LGICs) superfamily, are
involved in signal transduction upon binding of the neurotrans-
mitter acetylcholine or exogenous ligands, such as nicotine.
nAChRs are pentameric assemblies of homologous subunits sur-
rounding a central pore that gates cation flux, and are
expressed at the neuromuscular junction and in the nervous
system and several nonneuronal cell types. The 17 known

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine