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This article was published as part of the C---H functionalisation in organic

Summary: This article was published as part of the
C---H functionalisation in organic
synthesis themed issue
Guest editors Huw M. L. Davies, Justin Du Bois and Jin-Quan Yu
Please take a look at the issue 4 2011 table of contents to
access other reviews in this themed issue
View Online
This journal is c The Royal Society of Chemistry 2011 Chem. Soc. Rev., 2011, 40, 2003­2021 2003
Enzymatic functionalization of carbon­hydrogen bondsw
Jared C. Lewis,a
Pedro S. Coelhob
and Frances H. Arnold*b
Received 6th August 2010
DOI: 10.1039/c0cs00067a
The development of new catalytic methods to functionalize carbon­hydrogen (C­H) bonds
continues to progress at a rapid pace due to the significant economic and environmental benefits
of these transformations over traditional synthetic methods. In nature, enzymes catalyze regio- and
stereoselective C­H bond functionalization using transformations ranging from hydroxylation to


Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology


Collections: Chemistry; Biology and Medicine