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Synaptic Plasticity in Local Cortical Network In Vivo and Its Modulation by

Summary: Synaptic Plasticity in Local Cortical
Network In Vivo and Its Modulation by
the Level of Neuronal Activity
Sylvain Crochet, Pablo Fuentealba, Youssouf CisseŽ ,
Igor Timofeev and Mircea Steriade
Laboratoire de Neurophysiologie, FaculteŽ de MeŽ decine,
UniversiteŽ Laval, QueŽ bec, Canada G1K 7P4
Neocortical neurons maintain high firing rates across all behavioral
states of vigilance but the discharge patterns vary during different
types of brain oscillations, which are assumed to play an important
role in information processing and memory consolidation. In the
present study, we report that trains of stimuli applied to local
neocortical networks of cats, at frequencies that mimic endoge-
nous brain rhythms, produced depression or potentiation of post-
synaptic potentials, which lasted for several minutes. This form of
synaptic plasticity was not mediated through NMDA receptors
since it persisted after blockade of these receptors, but was
strongly modulated by the level of background neuronal activity.
Using different preparations in vivo, we found that increased
background neuronal activity decreased the probability of plastic


Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra


Collections: Computer Technologies and Information Sciences