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128 Current Pharmaceutical Biotechnology, 2010, 11, 128-137 1389-2010/10 $55.00+.00 2010 Bentham Science Publishers Ltd.
 

Summary: 128 Current Pharmaceutical Biotechnology, 2010, 11, 128-137
1389-2010/10 $55.00+.00 2010 Bentham Science Publishers Ltd.
Magnetic Modulation Biosensing for Rapid and Homogeneous Detection of
Biological Targets at Low Concentrations
Amos Danielli1,*
, Noga Porat2
, Marcelo Ehrlich3
and Ady Arie1
1
Department of Physical Electronics, Faculty of Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel; 2
Department
of Biological Science, University of Illinois at Chicago, Chicago IL 60607, USA; 3
Department of Cell Research and Im-
munology, Tel-Aviv University, Tel-Aviv 69978, Israel
Abstract: This paper reviews the development of a magnetic modulation biosensing (MMB) system for rapid, simple and
sensitive detection of biological targets in homogeneous solution at low concentrations. It relies on condensation and
modulation of the fluorescent-labeled probes attached to magnetic beads using an alternating magnetic field gradient.
Condensation of the beads from the entire volume increases the signal while modulation separates the signal from the
background noise of the non-magnetized solution. We first discuss the motivation and challenges in specific DNA se-
quences detection as well as current approaches to overcome some of these challenges. We then present the MMB system,

  

Source: Arie, Ady - Department of Electrical Engineering-Physical Electronics, Tel Aviv University

 

Collections: Engineering