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Copyright 2008 by the Genetics Society of America DOI: 10.1534/genetics.107.083923

Summary: Copyright 2008 by the Genetics Society of America
DOI: 10.1534/genetics.107.083923
DAF-16-Dependent Suppression of Immunity During
Reproduction in Caenorhabditis elegans
Sachiko Miyata,* Jakob Begun,*,
Emily R. Troemel*,
and Frederick M. Ausubel*,,1
*Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114 and
Department of Genetics,
Harvard Medical School, Boston, Massachusetts 02115
Manuscript received July 27, 2007
Accepted for publication November 21, 2007
To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack,
we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also
examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility
and pathogen resistance are highly correlated and that resistance in both epr and sterile mutants is
dependent on DAF-16 activity. Our data indicate that a DAF-16-dependent signaling pathway distinct from
previously described pathways is involved in the activation of genes that confer resistance to bacterial
pathogens. The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of


Source: Ausubel, Frederick M. - Department of Genetics, Harvard University


Collections: Biology and Medicine